1-s2.0-S1879625718300348-gr1 lrg

Description:

Description: English: Assembly and pre-genome packaging in members of the Cystoviridae family. (1) Newly transcribed l+, m+, and s+RNAs are extruded from the procapsid. (2) Viral proteins P1 (core protein, purple), P2 (RdRP, red), P4 (RNA helicase/packaging motor, green), and P7 (assembly co-factor, yellow) co-assemble (3) forming new empty procapsids. (4) Assembled procapsids sequentially recruit RNAs, which are translocated inside the core by a hexameric packaging motor P4 in the order s+, m+, and l+. RNA packaging results in expansion of the procapsid. (5) After packaging, multiple + RNAs are replicated inside the procapsid by P2, forming dsRNAs. Date: 1 December 2018. Source: https://www.sciencedirect.com/science/article/pii/S1879625718300348#bib0245. Author: Alexander Borodavka, Ulrich Desselberger, and John T Patton.