Doi.10.1128.JVI.00175-20.F2.large

Description:

Description: English: The domain organization and architecture of L and P. (A) The domain organization and cartoon representation of the multifunctional enzyme monomeric L. The conserved regions (CRs) I to VI are labeled in gray boxes. The RNA-dependent RNA polymerization domain (RdRp), capping domain (Cap), connector domain (CD), methyltransferase domain (MT), and C-terminal domain (CTD) of L are colored in blue, green, yellow, pink, and cyan, respectively. (B) The domain organization and cartoon representation of the multimodular adapter oligomeric P. The intrinsically disordered N-terminal domain (PNTD), oligomerization domain (POD), and C-terminal domain (PCTD) are colored in magenta, red, and orange, respectively. The interaction regions with other viral proteins, including L, N, RNA-free N (N0), and accessory protein (M2-1), are labeled in gray boxes. The representative P oligomers are shown for the representative virus families Rhabdoviridae, Pneumoviridae, Paramyxoviridae, and Filoviridae. Date: 27 October 2020. Source: Liang B. 2020. Structures of the Mononegavirales polymerases. J Virol 94:e00175-20. https://doi.org/10.1128/JVI.00175-20. Author: Bo Liang.