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Orthohepadnavirus

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Orthohepadnavirus is a genus of viruses, in the family Hepadnaviridae.[1] Humans and other mammals serve as natural hosts. There are 12 species in this genus.[1] Diseases associated with this genus include: hepatitis, hepatocellular carcinoma (chronic infections), and cirrhosis.[1][2]

Taxonomy

The genus contains the following species:[3]

Structure

Viruses in the genus Orthohepadnavirus are enveloped, with spherical geometries, and T=4 symmetry. The diameter is around 42 nm. Genomes are circular, around 3.2kb in length. The genome codes for 7 proteins.[1][2]

Life cycle

Viral replication is nucleo-cytoplasmic. Replication follows the dsDNA(RT) replication model. DNA-templated transcription, specifically dsDNA(RT) transcription, with some alternative splicing mechanism is the method of transcription. Translation takes place by leaky scanning. The virus exits the host cell by budding, and nuclear pore export. Human and mammals serve as the natural host. Transmission routes are sexual, blood, and contact.[1][2]

References

  1. ^ a b c d e "ICTV Report Hepadnaviridae".
  2. ^ a b c "Viral Zone". ExPASy. Retrieved 15 June 2015.
  3. ^ "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 21 May 2021.

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Orthohepadnavirus: Brief Summary

provided by wikipedia EN

Orthohepadnavirus is a genus of viruses, in the family Hepadnaviridae. Humans and other mammals serve as natural hosts. There are 12 species in this genus. Diseases associated with this genus include: hepatitis, hepatocellular carcinoma (chronic infections), and cirrhosis.

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cc-by-sa-3.0
copyright
Wikipedia authors and editors
original
visit source
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wikipedia EN