Guaiacum sanctum is a species of shrub in the family Zygophyllaceae. They have a self-supporting growth form. They are listed as near threatened by IUCN and in cites appendix ii. They are native to Puerto Rico, The Contiguous United States, and The Neotropics. They have simple, broad leaves, blue flowers, and loculicidal capsule fruit. Flowers are visited by Florida or Tropical White and Phoebis agarithe. Individuals can grow to 15 m.
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