Roughleaf Dogwood

Cornus drummondii C. A. Mey.

are eaten by

• Global Biotic Interactions: Calligrapha (Calligrapha) scalaris (J. E. Le Conte 1824) (Elm Calligrapha)
• Global Biotic Interactions: Apis mellifera Linnaeus 1758 (Honey bee)
• Global Biotic Interactions: Analeptura lineola (Say 1824)
• Global Biotic Interactions: Syritta pipiens (Linnaeus 1758)
• Global Biotic Interactions: Strymon melinus Hübner 1818 (Gray Hairstreak)

are host of

• Global Biotic Interactions: Oliveros mammarenavirus
• Global Biotic Interactions: Verpa digitaliformis Pers. 1822
• Global Biotic Interactions: Coleophora cornella
• Global Biotic Interactions: Synchytrium corni M. T. Cook 1953
• Global Biotic Interactions: Synchytrium corni M. T. Cook 1953

are visited by

• Global Biotic Interactions: Chauliognathus marginatus
• Global Biotic Interactions: Prenolepis imparis (Say 1836) (False Honey Ant)

have flowers visited by

• Global Biotic Interactions: Vanessa virginiensis
• Global Biotic Interactions: Euderces picipes (Fabricius 1787)
• Global Biotic Interactions: Polistes apachus de Saussure 1857
• Global Biotic Interactions: Polygonia interrogationis Fabricius 1798 (Question Mark)
• Global Biotic Interactions: Asterocampa celtis Boisduval & Leconte 1833 (Hackberry Emperor)